Andrea standing near Neil Gaiman as he patiently signs all of the books she brought

Andrea and her BFF Neil Gaiman

 

 Andrea MacFadden

Andrea.MacFadden@cuanschutz.edu

"I am studying the effects of how the xrRNAs within the 3' UTRs of flaviviruses affect degradation by a variety of ribonucleases. I am hoping this will allow us to crystallize these diverse xrRNAs to discover their structures, 'cause that's what we do in the Kieft lab. In my spare time also serve as the lab protein vending machine."

Andrea joined the lab with lots of experience expressing and purifying proteins. We have converted her to the RNA world...although she is still a Redwings fan...we have to work on that.

 Publications in the Kieft Lab

  1. Bonilla S, Sherlock ME, MacFadden A, Kieft JS (2021) A structured viral RNA uses molecular mimicry and conformational dynamics to coordinate multiple functions. Science [Accepted].

  2. Franklin AL, MacFadden A, Kieft JS, Hesselberth JR, Chapman EG (2021) Custom-designed, degradation-resistant messenger RNAs in yeast. RNA Biology [In Revision].

  3. Langeberg CJ, Sherlock ME, MacFadden A, Kieft JS (2021) An expanded class of histidine-accepting viral tRNA-like structures. RNA 27, 653 – 664.

  4. Sherlock ME, Hartwick EW, MacFadden A, Kieft JS (2021) Structural diversity and phylogenetic distribution of valyl tRNA-like structures in viruses. RNA 27, 27 – 39.

  5. Hartwick EW, Costantino DA, MacFadden, A, Nix JC, Tian S, Das R, Kieft JS (2018) Ribosome-induced RNA conformational changes in a viral 3′-UTR sense and regulate translation levels. Nat Commun 9, 5074.

  6. MacFadden A, O’Donoghue Z, Silva, PAGC, Chapman EG, Olsthoorn RC, Sterken MG, Pijlman GP, Bredenbeek PJ, Kieft JS (2018) Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs. Nat Commun 9, 119 (2018).