We are fascinated by RNA, the most versatile biological macromolecule. While DNA might be thought of as a ‘tape’ that stores information, and proteins as ‘shapes’ that carry out specific functions, RNA does both. This remarkable functional diversity is due to RNA’s ability to form complex 3-D structures – this is what we seek to understand. How does RNA fold into complex shapes, and what do these structures look like? What do they interact with in the cell? How does this create function? We are particularly interested in RNAs from viruses, how they relate to disease, and how we might exploit this knowledge to improve human health.